What is Ghosez’s Reagent?
CAS: 26189-59-3 | Eburon Organics ref. 101.810
1-Chloro-N,N,2-trimethyl-1-propenylamine or Tetramethyl-α-chloroenamine is called after Professor L. Ghosez (Synthetic Organic Chemistry Laboratory, University of Louvain, Belgium).
Ghosez reagent is a halogenation reagent which converts carboxylic acids into the corresponding chlorides under neutral conditions.
Applications of Ghosez’s Reagent
Other application of Ghosez’s reagent involve conversion of N-protected amino acids into peptides without racemisation, coupling of acids and allylic alcohols with organometallics, and mild halogenation of alcohols under neutral conditions.