101210
1,2,3-Thiadiazole-4-carbaldehyde
1,2,3-Thiadiazole-4-carbaldehyde 1 is a crystalline solid ( mp 87°C) which is thermally stable to >150°C and slighly light sensitive. 1 has been coupled as a lipophilic moiety to cephalosporin antibacterials(1). The imine derivatives of 1 rearrange to 1,2,3-triazole derivatives on heating (2). Aldehyde 1 has been converted to 4,4-diformyltetrathiafulvalene (3) and other extended TTFs (4).
References:
(1). T. Kobori, M. Fujita, T. Hijama, K. Kondo Synlett, 1992, 95
(2). G. Labbé, M. Verbeke, W. Dehaen, S. Toppet, J. Chem. Soc. Perkin Trans. 1, 1993 , 1719
(3). R. Andreu, J. Garin, J. Orduna, M. Saviron, J. Cousseau, A. Gorgues, V. Morisson, T. Nozdryn, J. Becher, R.P. Clausen, M.R. Bryce, P.J. Skabara , W. Dehaen, "The Synthesis of 4,4'(5')-Diformyltetrathiafulvalene", Tetrahedron Lett., 1994,35, 9243-9246
(4). R. P. Clausen, J. Becher Tetrahedron 1996,52, 3171
